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14 December 2017
 
 Alireza Garjani ,Ph.D

Title:       Professor of Pharmacology 
Department:  Pharmacology     
Office Phone:+98(41)33372252     
Fax:         +98(41)33344798             
E-mail:      garjania@tbzmed.ac.ir 

Personal Details:

Date of Birth:            December 22, 1960

Place of Birth:            Ardabil; Iran

Nationality:                Iranian

Sex:                         Male

Marital Status:           Married with three children

Address:                  Deartment of Pharmacology; Faculty of Pharmacy; Tabriz University of Medical Sciences; Tabriz, Iran.

Tel:                          +98-411-3372252

Fax:                         +98-411-3344798

E-mail:                      garjania@tbzmed.ac.ir  and  garjania2002@yahoo.com


Education:

 1980-1986                Pharm D., School of Pharmacy; Tabriz University; Tabriz; Iran

 1991-1995                Ph. D., Department of Physiology and Pharmacology, Strathclyde University, Glasgow, U.K.

 2003                         Sabbatical period in Hatter Institute at University College London

 
Thesis:

Ph.D thesis: Endothelin in the healthy and ischaemic myocardium; Under supervision of Prof. Zeitlin I.J. and Dr. Wainwright C.L.; 1995; University of Strathclyde; Glasgow; U.K.

Pharm.D thesis: Enhancement of solubility of metronidazol; Under supervision of Prof. Barzegar-Jalali M., 1986; Tabriz university; Tabriz, Iran

 
Teaching and Working Experiences:

1987-1991: As a lecturer: Teaching Drug Information, Pharmacology for Pharmacy, Medicine, Nursing and Midwifery students; Tabriz University of Medical Sciences

1996-1999: As an assistant professor: Dean of Tabriz School of Pharmacy; Teaching Cardiovascular and Endocrine Pharmacology for Pharmacy, Medicine and Ph.D students; Supervising of Pharm D. and Ph.D students

1999-2005: As an associated professor: Head of the Pharmacology Department; Vice Chancellor in Food and Drug Affairs of Tabriz University of Medical Sciences; Teaching Cardiovascular and Endocrine Pharmacology for Pharmacy, Medicine and Ph.D students; Supervising of Pharm D. and Ph.D students

2005-now : Professor of pharmacology; Teaching Cardiovascular and Endocrine Pharmacology for Pharmacy, Medicine and Ph.D students; Supervising of Pharm D. and Ph.D students


Research interest

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction is a common clinical event and occurs when blood flow to a part of the heart is blocked for a long enough time that part of the myocardial muscle is damaged or dies.  It has been established that myocardial infarction is strongly associated with inflammatory responses. An increasing body of evidence has indicated that initiation of left ventricular remodeling after MI is largely connected with intense autoimmune inflammatory response to cardiac infiltration of immune cells. Ischemia and reperfusion initially mediate oxidative stress and neutrophil activation, which in turn lead to the release of proteases and toll like receptors (TLRs) activation. It was originally thought that the innate immune response through TLRs activation was designed to protect the body against invading pathogens. However, a large number of studies have reported that various endogenous ligands acting as ‘danger signals’, also called danger-associated molecular patterns (DAMPs), are released upon myocardial injury, which activate the TLRs. AMPK (AMP activated protein kinase) is an enzyme that participates in the cellular response to metabolic stress when; the AMP:ATP ratio is elevated. AMPK activation helps to reserve cellular energy stores during ischemia and protects the heart against ischemic injuries. It is also possible that AMPK functions to inhibit inflammation, as we have indicated that administration of metformin, an AMPK activator, at MI preserves cardiac function and suppresses inflammatory responses. These effects are associated with increase in AMPK activity in part as well as reduction of TLRs activity. AMPK activation by metformin and the subsequent suppression of TLR4 expression and activity can be considered as a target in protecting the infarcted heart and may indicate a link between AMPK and TLRs. Our experimental approach uses intact and isolated rat heart models to examine key mechanisms in myocardial infarction that 1) affect recovery of LV mechanical and metabolic function, 2) regulate AMPK activity, and 3) influence TLRs expression and activity. Drug and natural product effects on mechanical function (LV work, ECG, cardiac efficiency), inflammatory responses, oxidative stress, and histopathological changes are also measured along with cell signaling events that regulate pathways of glycogen and glucose utilization (GSK-3β, ACC, AMPK) and TLRs activity (TLR4 expression and content, MYD88 myocardial levels, TNFα, and IL6 tissue and serum concentrations).

 

Some Current Projects:

The role of AMPK in cardiac remodeling induced by acute myocardial infarction

The effect of A-769662, a direct AMPK activator, on hemodynamic changes, cardiac biomarkers, and on inflammatory cytokines in myocardial infarction induced by isoproterenol in rats

The effect of metformin on leukocytes infiltiration and activity and tissue injury in myocardial infarction induced by isoproterenol in rats

Study of Toll-like receptor 4 expression and activity in patients undergoing PCI (Percutaneous Coronary Intervention)

Study of the effect of A-769662, a direct AMPK activator, on myocardial function and TLR4 activity in isolated rat hearts under LPS perfusion.

Study of cardipoprotective effects of several natural compounds and extracts against myocardial infarction in animal model.

 

Book
Nasrin Maleki and Alireza Garjani, Midwifery Clinical Pharmacology (in Farsi); Tabriz university of  Medical Sciences; Tabriz –Iran, 2001

  Publications

Pooya Olyaee, Behnam Mirzakouchaki, Kavoos Ghajar, Seyyed Amir Seyyedi, Majid Shalchi, Alireza Garjani, Esmaeil Dadgar. The effect of oral contraceptives on orthodontic tooth movement in rat. Med Oral Patol Oral Cir Bucal, 2013, 1, 18(1): e146-50.

Sadollah Mohammadi, Alireza Garjani*, Moslem Najafi, Hossein Hamzeiy, Nasrin Maleki-Dizaji, Yadollah Omidi, Shabnam Fayezi, Masoud Darabi, Sara Mostafalou, Kambiz Hassanzadeh and Sajjad Khani. Inhibitory effects of methylsulfonylmethane on vascular hypertrophy related gene expression. International Journal of Pharmacology, 2012. DOI: 10.3923/ijp2012.

Fathiazad F., Matlobi A., Khorrami A., Hamedeyazdan S., Soraya H., Hammami M., Maleki-Dizaji N., *Garjani A. Phytochemical screening and evaluation of cardioprotective activity of ethanolic extract of Ocimum basilicum L. (basil) against isoproterenol induced myocardial infarction in rats. DARU Journal of Pharmaceutical Sciences, 2012, 20:87: doi:10.1186/2008-2231-20-87

Sadollah Mohammadi, Moslem Najafi, Hossein Hamzeiy, Nasrin Maleki-Dizaji, Masoud Pezeshkian, Homayon Sadeghi-Bazargani, Masoud Darabi, Sara Mostafalou, Shahab Bohlooli, and Alireza Garjani*. Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats. Advances in Pharmacological Sciences, 2012, Article ID 507278, 6 pages.

Hamid Soraya, Safar Farajnia, Sajjad khani, Maryam Rameshrad, Arash Khorrami, Armita Banani, Nasrin Maleki-Dizaji, Alireza Garjani*. Short-term treatment with metformin suppresses toll like receptors (TLRs) activity in isoproterenol-induced myocardial infarction in rat: Are AMPK and TLRs connected?" International Immunopharmacology; 2012, 14(4): 785–791.

Bagheri B, Sohrabi B, Movassaghpur A, Mashayekhi S, Garjani A*, Shokri M, Noori M, Garjani A. Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention. Iranian Journal of Immunology. 2012, 9(3): 149-158.

Armita Banani, Nasrin Maleki-Dizaji*, Alireza Garjani, Sara Mostafalou, Mojtaba Ziaee. Clavulanic acid exhibits anti-inflammatory effects on carrageenan-induced paw edema model of inflammation in rats. Annals of Biological Research, 2012, 3 (7):3312-3320.

Hamid Soraya, Arash Khorrami, Afagh Garjani, Nasrin Maleki-Dizaji, Alireza Garjani*. Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.Pharmacological Reports, 2012, 64(6 ): 1476-1484.

Armita Banani, Nasrin Maleki-Dizaji*, Hossein Niknahad, Alireza Garjani, Mojtaba Ziaee, Hamed Ghavimi, Sanaz Hamedeyazdan1 and Afagh Garjani. N-acetylaspartylglutamate (NAAG) exhibits antiinflammatory effects on carrageenan-induced paw edema model of inflammation in rats. African Journal of Pharmacy and Pharmacology. 2012; 6(23): 1702-1709.

Kavoos Ghajar , Pooya Olyaee , Behnam Mirzakouchaki , Loghman Ghahremani , Alireza Garjani , Esmaeil Dadgar , Sahel Marjani.  The effect of pregnancy on orthodontic tooth movement in rats. Med Oral Patol Oral Cir Bucal, 2012, -AHEAD OF PRINT.

Alireza Garjani*, Hassan Rezazadeh, Sina Andalib, Mojtaba Ziaee, Yousef Doustar, Hamid Soraya, Mehraveh Garjani, Arash Khorrami, Nasrin Maleki-Dizaji. Ambivalent effects of atorvastatin on angiogenesis, epidermal cell proliferation and tumorgenesis in animal models. Iranian Biomedical Journal,  2012, 16 (2): 59-67.

Hamid Soraya, Nilufar Esfahanian, Yadollah Shakiba,  Mahmood Ghazi-Khansari, Behroz Nikbin, Hasan Hafezzadeh, Nasrin Maleki Dizaji,  Alireza Garjani *. Anti-angiogenic effects of metformin, an AMPK activator, on human umbilical vein endothelial cell and on granulation tissue in rat. Iranian Journal of Basic Medical Sciences,  2012, 15(6): 10202-10209.

Mojtaba Ziaee, Mohammad A. Eghbal*, Mohammad Ghaffarzadeh and Alireza Garjani. Comparison of hepatoprotective effects of clofibrate and its novel siliconized analogue in isolated rat hepatocytes. Annals of Biological Research, 2012, 3 (4):1895-1903.

Mojtaba Ziaee, Morteza Samini, Mohammad Bolourtchian, Mohammad Ghaffarzadeh, Mohammad Ali Egbalc, Maryam Ahmadi, Arash Khorrami, Sina Andalib, Nasrin Maleki-Dizaji, Alireza Garjani*. Synthesis of a novel siliconized analog of clofibrate (silafibrate) and comparison of their anti-inflammatory activities. Iranian Journal Of Pharmaceutical Research, 2012, 11(1): 91-95.

Mojtaba Ziaee, Mehdi Rasouly, Arash Khorrami, Sina Andalib, Alireza Garjani*. The effect of pentoxifylline on leukocyte accumulation and angiogenesis in an air pouch model in rat. Journal of Chemical and Pharmaceutical Research, 2012, 4(1):402-408.

Hafezzadeh Hassan, Soraya Hamid, Banani Armita, Adibpour Mohammad, Maryam Rameshrad, Garjani Alireza, Maleki Dizaji Nasrin*. The Effect of Metformin on Neutrophil Recruitment in Carrageenan- Induced Peritonitis in Mice. Pharmaceutical Sciences, 2012, 17(4): 209 – 218 (in farsi)

Arash Afrooziyan, Davoud Noruozi, Hamed Ghavimi, Hossein Nazemiyeh, Nasrin Maleki Dizaji, Alireza Garjani*. The Comparative Effects of different fractions of hydroalcoholic extract of Cynodon dactylon (L.) pers. rhizome on hemodynamic and contractility function of isolated rat heart. Pharmaceutical Sciences, 2012, Vol. 17, No 4, Page 233-242 (in Farsi)

Yousef Doustar, Daryoush Mohajeri, Alireza Garjani, Ghafour Mousavi, Mehrdad Neshat Ghramaleki. Protective Effect of Metformin on Cardiomyocytes Ischemia-Reperfusion (IR) Induced Apoptosis in Rats. Journal of Animal and Veterinary Advances, 2012; 11(1), 108-112.

Nilufar Esfahanian, Yadollah Shakiba, Behroz Nikbin, Hamid Soraya, Nasrin Maleki-Dizaji, Mahmood Ghazi-Khansari, Alireza Garjani*. Effect of metformin on the proliferation, migration, and MMP-2 and -9 expressions of human umbilical vein endothelial cells (HUVECs). Molecular Medicine Reports, 2012, 5:1068-1074.

Garjani A, Andalib S, Biabani S, Soraya H, Doustar Y, Maleki-Dizaji N. Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. European Journal of Pharmacology, 2011, 666(1-3):135-141.

Esfahanian N, Shakiba Y, Ghazi-Khansari M, Nikbin B, Maleki-Dizaji N, Garjani A*.          EFFECTS OF METFORMIN ON ANGIOGENESIS ASSESSED AS PROLIFERATION AND MIGRATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. Inflammation Research.  2011; 60:84-85.

Banani A, Mostafalou S, Garjani A, Maleki-Dizaji N. NAAG REDUCES NEUTROPHIL INFILTRATION AND EDEMA RESPONSE IN CARRAGEENAN-INDUCED ACUTE INFLAMMATION. Inflammation Research. 2011, 60:209-209.

Najafi M, Javidnia A, Ghorbani-Haghjo A, Mohammadi S, Garjani A*. PHARMACOLOGICAL PRECONDITIONING WITH L-CARNITINE: RELEVANCE TO MYOCARDIAL HEMODYNAMIC FUNCTION AND GLYCOGEN AND LACTATE CONTENT. Pakistan Journal of Pharmaceutical Sciences,  2010;23(3): 250-255.

Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, Maljaie SH, Garjani A. The effects of 5HT(3) receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. International Immunopharmacology. 2010,10(9): 1010-1016.

Eghbal MA, Ziaee M, Garjani A, et al. Comparison of the effects of the Clofibrate and its siliconized analogue in freshly isolated rat hepatocytes. Drug Metabolism Reviews. Aug 2010;42:164-165.

Garjani A, Afrooziyan A, Nazemiyeh H, Najafi M, Maleki-Dizaji N. Effects of total extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats. Planta Medica. Jul 2009;75(9):1043-1043.

Garjani A, Fathiazad F, Zakheri A, Allaf-Akbari N, Azarmie Y, Maleki-Dizaji N. The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles and vascular function in hypercholesterolemic rats. Planta Medica. Jul 2009;75(9):1012-1013.  

Garjani A
, Fathiazad F, Zakheri A, et al. The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats. Journal of Ethnopharmacology. Dec 2009;126(3):525-532. 
 
Garjani A, Afrooziyan A, Nazemiyeh H, Najafi M, Kharazmkia A, Maleki-Dizaji N. Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats. Bmc Complementary and Alternative Medicine. Aug 2009;9.

Najafi M, Nazemiyeh H, Ghavimi H, Gharakhani A, Garjani A. Effects of hydroalcoholic extract of Cynodon dactylon (L.) pers. on ischemia/reperfusion-induced arrhythmias. Daru-Journal of Faculty of Pharmacy. Fal 2008;16(4):233-238.

Najafi M, Garjani A, Maleki N, Oskouei TE. Antiarrhythmic and arrhythmogenic effects of L-carnitine in ischemia and reperfusion. Bulletin of Experimental Biology and Medicine. Aug 2008;146(2):210-213.

Maleki-Dizaji N, Nazemiyeh H, Maddah N, Mehmani F, Garjani A. Screening of extracts and fractions from aerial parts of stachys schtschegleevii sosn. For anti-inflammatory activities. Pakistan Journal of Pharmaceutical Sciences. Oct 2008;21(4):338-343.

Garjani A, Rezazadeh H, Andalib S, Ziaee M, Maleki N. Mevalonate independent effects of atorvastatin on angiogenesis: Relevance to cancer. Journal of Molecular and Cellular Cardiology. Apr 2008;44(4):720-720.

Garjani A, Andalib S, Ziaee M, Maleki-Dizaji N. Biphasic effects of atorvastatin on inflammation. Pakistan Journal of Pharmaceutical Sciences. Apr 2008;21(2):125-130.

Nazemiyeh, Maleki N, Mehmani F, et al. Assessment of anti-inflammatory properties of ethyl acetate extract of Stachys schtschegleevii Sosn. Daru-Journal of Faculty of Pharmacy. Win 2007;15(4):174-182.  

Najafi M, Nazemiyeh H, Garjani A, Ghavimi H, Gharekhani A. Anti-inflammatory action is probably responsible in the cardioprotective effects of Cynodon Dactylon during ischemia/reperfusion. Inflammation Research. Jun 2007;56:S451-S452.

Najafi M, Nazemiyeh H, Garjani A, Ghavimi H, Gharekhani A. Cardioprotective effects of Cynodon Dactylon against ischemia/reperfusion-induced arrhythmias. Journal of Molecular and Cellular Cardiology. Jun 2007;42:S12-S12.

Maleki-Dizaji N, Fathiazad F, Garjani A. Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa. Archives of Pharmacal Research. Dec 2007;30(12):1536-1542.

Garjani A, Andali S, Ziaee M, Doustar Y, Maleki N. Comparison of anti-inflammatory and anti-leukocyte accumulation effects of statins. Acta Pharmacologica Sinica. Jul 2006;27:262-262.

S. Dastmalchi, a, N. Maleki,  G. Sheikhee, V. Baghchevan, P Jafari, H. Valizadeh & M. Barzegar Jalali.A.Garjani.  Enhancing dissolution, serum concentration and hypoglycemic effect of glibenclamide using solvent deposition technique. J Pharm. Pharmaceut. Sci. 2005, 8(2), 175-181

Nasrin Maleki, Alireza Mohajjel Nayebi, Alireza Garjani. (2005) Effects of central and peripheral depletion of serotonergic system on carrageenan-induced paw oedema. International Immunopharmacology , 5, 1723-1730

H. Rezazadeh, AR. Nayebi, A. Garjani, A. Sheikhulislami, H. Babaei. (Agust 2005)   Evidence that iron-overload plus croton oil induced skin tumours in mice. Human & Experimental Toxicology, vol24, No 8: 409-413

A. Garjani, M. Najafi & N. Maleki. (2005) The Effects of L-carnitine on Ischemic and reperfusion arrhythmias in isolated rat hearts. Medimond S.r.l., 25th European section Meeting – International Society for Heart Research Proceeding, p: 33-37 

M. Najafi, A. Garjani & Y. Doustar. (2005) Cardioprotective effects of L-carnitine on myocardial ischemia and reperfusion injury in isolated rat hearts.  Medimond S.r.l., 25th European section Meeting – International Society for Heart Research Proceeding, p: 63-67

 N. Maleki, A. Garjani, R. Salehi and J. Lotfipoor. (2005) The Effects of Diltiazem on QT-interval duration and dispersion in patients with unstable Angina. Medimond S.r.l., 25th European section Meeting – International Society for Heart Research Proceeding, p: 59-63

 A.Garjani, K. Abedinogli, M. Shamsmohammadi, M. salimnejad, N. Maleki. (1384 S.C; 2005 A.D) The Study Of Adverse Drug Reaction To Streptokinase In Inpatients With Acute Myocardial Infarction In Shahid Madani Hospital For Cardiovascular Disease In Tabriz Between 1999 and 2001. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences. Summer (2005) 65-69 (in Farsi) 

 M. Najafi, A. Garjani (1384 S.C; 2005 A.D) Study the Effects of L-carnitine on infarct size in ischemic-reperfused isolated rat hearts. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences, spring, No 1, 47-51 (in Farsi) 

A. Garjani, M. Najafi. (1384 S.C; 2005 A.D) The effects of L-carnitine on Ischemic-reperfusion induced arrhythmias in rat heart. Iranian Journal of Basic Medical Sciences, vol 8, No 1, Spring 2005, 38-43 (in Farsi)

Maleki N, Mohajjel Nayebi A., Garjani A., Fakhrjou A.  Effects of central and peripheral depletion of serotonergic system on carrageenan induce paw oedema. Pharmaceutical Sciences, 2005, 75-84 (in Farsi)   

Fatemeh Fathi Azad; Alireza Garjani; Nasrin Maleki and sodaif Ranjdost  Study of the hypoglycemic activity of the hydroalcoholic extract of Urtica dioica in normal and diabetic rats. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences, Summer 2005, 65-69, (in Farsi)  

A.Garjani, N. Maleki, H. Nazemyeh.  Effects of hydroalcoholic extract from aerial parts of the sterile stems of stachys inflata on myocardial infarct size in rats. Iranian Journal of Pharmaceutical Research, 2004, 3:165-170.

Alireza Garjani, Soodabeh Davaran, Mohamadreza Rashidi and Nasrin Maleki (2004) Protective effects of some Azo derivatives of 5-aminosalycylic acid and their PEGylated prodrugs on acetic acid induced rat colitis. DARU,  12 (1): 24-30.

A. Garjani, M. Najafi, E. Bayat, O. Moolavi. (1383 S.C; 2004 A.D) Prescription pattern of drugs acting on the central nervous system in Tabriz in 1999. Journal of Medical Council of ISRI. No 3 (Autumn): 171-264 (in Farsi)

Garjani A., Maleki N., Eterafoskouei Z., et al (1382 S.C ; 2003 A.D) Topical anti-inflammatoryactivity of stachys inflata on carrageenan and UV induced inflammation on rats. Pharmaceutical Sciences Journal of Tabriz Faculty of Pharmacy No 1; 58-64 (in Farsi)

M. Barzegar-Jalali, N. Maleki, A. Garjani, A.A. Khandar, M. Haji-Hosseinloo, R. Jabbari, and S. Dastmalchi (2002) Enhancement of dissolution rate and anti-inflammatory effects of piroxicam by using solvent deposition technique. Drug Development and Industrial Pharmacy; 28(6), 681-686

A. Garjani, M. Shamsmohamadi, N. Maleki (1381 S.C; 2002 A.D) A lesson from a medical error. Daru and Darman, No 20, 21-22 (in Farsi)

N. Maleki, A.Garjani,  H. Nazemiyeh, N. Nilfouroushan, A.T. Eftekhar Sadat, Z. Allameh & N. Hasannia (2001). Potent Anti-Inflammatory of Hydroalcoholic Extract from Aerial Parts of Stachys Inflata on Rats. Journal of Ethnopharmacology, 75, 213-218

A. Garjani, H. Nazemiyeh, N. Maleki & H. Valizadeh (2000). Effects of Extracts from Flowering Tops of  Carataegus meyeri A. Pojark. On Ischaemic Arrhythmias in Anaesthetized Rats. Phytotherapy Research, 14, 428-431.

A. Garjani, N. Maleki, A. Mahdinia, Babaei H. (Feb. 2000). Hypoventilation Prior To Ischemia Preconditions Rat Myocardium. Medical Journal of the Islamic Republic of Iran, Vol 13, No 4, 297-302.

Parvizi R., Hejazi M.S., Jelvegari M., Hassanzadeh D., Garjani A., Babaei H. & Azizian P. (1377 S.C; 1998 A.D) Formulation of  Cardioplegia Ampule and Comparison of Its in-vitro Characters and in-vivo Effects with Foreigner Sample. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences, Vo4, No 2, 94-101 (in Farsi)

Maleki Dizaji N., Garjani A.., Pyne S. (1998) Sphingomyelin metabolits as second messangers in airway smooth cell proliferation. Medical Journal of the Islamic Republic of Iran, Vol 12, No 1, 57-63

H. Hamzehe, N. Maleki & A. Garjani ( 1376 S.C; May 1997 A.D) Cyclosporin. J. of Nabz. Vol 6, No 8, 49-55 (in Farsi)

Garjani A., Maleki D.N. & Zeitlin I.J. (1997). Raised plasma endothelin accompanying myocardial ischaemia in rats dose not originate in the myocardium. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences, No1,Vol 4, 57-66

A. Garjani, N. Maleki, I.J. Zeitlin & C.L. Wainwright (1996) pH dependent degradation of ET-1 by rat ventricular homogenate. Pharmaceutical Sciences Journal of Faculty of Pharmacy, Tabriz University of Medical Sciences, Vol3, No 3, 178-195

I.J. Zeitlin, G. A. Deuchar, M. Ahmad & A. Garjani (1996) Modulation of kinin outflow from isolated perfused rat hearts by ET-1. Immunopharmacology, 33, 294-296

Garjani A., Wainwright C.L., Zeitlin I.J., Wilson C. & Slee S.J. (1995) Effects of endothelin-1 and the ETA-receptor antagonist, BQ123, on ischaemic arrhythmias in anaesthetized rats. J. Cardiovascular Pharmacol., 25, 634-642
 

  Presentations

Alireza Garjani*, Hamid Soraya, Safar Farajnia, Maryam Rameshrad, Arash Khorrami, Banani Armita, Nasrin Maleki-Dizaji. The possible connection between AMP-activated protein kinase (AMPK) and toll-like receptors (TLRs) in myocardial infarction. Oral presentation in 13th Iranian Pharmaceutical Sciences Congress. 3-6 September 2012. Isfahan, Iran.

 Nasrin Maleki-Dizaji*, Armita Banani, Hossein Niknahad, Alireza Garjani,  Hamed Ghavimi. Anti-inflammatory Effects of Clavulanic Acid in Carrageenan Induced Paw Edema in Rats. Oral presentation in 13th Iranian Pharmaceutical Sciences Congress. 3-6 September 2012. Isfahan, Iran.

 Maryam Rameshrad, Keyvan Yousefi, Fatemeh Fathiazad, Hamid Soraya, Sanaz Hamedeyazdan, Arash Khorrami, Nasrin Maleki-Dizaji, Alireza Garjani. A methanolic extract of Marrubium vulgare L. suppresses inflammatory responses in isoproterenol induced myocardial infarction in rat. Oral presentation in 13th Iranian Pharmaceutical Sciences Congress. 3-6 September 2012. Isfahan, Iran.

 Yousefi K, Soraya H, Fathiazad F, Hodaei D, Rameshrad M, Maleki-Dizaji N, Garjani A.Cardioprotective effect of methanolic extract of Marrubium vulgare L. on isoproterenol-induced acute myocardial infarction in rats. 13th Congress of the International Society for Ethnopharmacology.  Graz, Austria September 2 - 6, 2012.

 Hodaei D,Yousefi K, Soraya H, Fathiazad F, Hamedeyazdan S, Maleki-Dizaji N, Garjani A. Digitally Enhanced Thin-Layer Chromatography and evaluation of in vivo and in vitro antioxidant activity of Marrubium vulgare L. 13th Congress of the International Society for Ethnopharmacology.  Graz, Austria September 2 - 6, 2012.

 A Garjani, H Soraya, S Farajnia, M Rameshrad, A Khorrami, A Banani, N Maleki-Dizaji. Activation of AMPK by metformin protects infarcted myocardium through suppression of tolllike receptor activity. 6th European Pharmacology Congress, Granada, Spain, 17-20 July 2012. Oral presentation

 Alireza Garjani, Bahram Sohrabi, Bahador Bagheri. Monocyte toll-like receptor 4 response following PCI (percutaneous coronary intervention). Circulation Vol 125, No 19 May 15, 2012; P569. Poster Presentations From the World Congress of Cardiology Scientific Sessions 2012 : Dubai, United Arab Emirates 18 -21 April 2012

 Bagheri B, Garjani A, Sohrabi B, Movassaghpour A, Garjani AF, Mashayekhi S, Noori M. Expansion of Circulating TollLike Receptor 4Positive Monocytes in Patients with Stable Angina.  Iranian Journal of Immunology, 2012, Vol 9, supplement 1, 553. 11th International Congress of Immunology and Allergy in Tehran, Iran

 Bagheri B, Garjani A, Sohrabi B, Movassaghpour A, Garjani AF, Mashayekhi S, Noori M. Monocyte expression of Tolllike receptor 4 (TLR4) and its association with TNFα in patients who undergo percutaneous coronary intervention.  Iranian Journal of Immunology, 2012, Vol 9, supplement 1, 554. 2012, 11th International Congress of Immunology and Allergy in Tehran, Iran

 Nilufar Esfahanian, Yadollah Shakiba, Behroz Nikbin, Nasrin Maleki-Dizaji, Mahmood, Ghazi-Khansari, Alireza Garjani*. Metformin inhibits VEGF release and mRNA expression in Human Umbilical Endothelial Cells (HUVECs) RedCat meeting 2012; Redox regulation - Natural compounds as regulators of inflammation signaling

 M. Ziaee, MA Egbal, J. Rahmani, M. Ghaffarzadeh, S. Andalib, A. Khorrami, M. Samini, A. Garjani. Evaluation of acute and subacute toxicity of a new clofibrate analogue (sikafibrate) in labaratory animals. 2nd International Congress of Veterinary Pharmacology; 13-14 December, 2011, Tehran, Iran.

 Sina Andali ، Arash Khorrami ، Alireza Garjani. Combined atorvastatin and coenzyme Q10 improve the left ventricular function in isoproterenol-induced heart failure in rat. 20th Iranian Congress of Physiology and Pharmacology; October 2011, Hammadan, Iran.

 hamid soraya ، nilufar esfahanian ، yadollah shakiba ، mahmood Ghazi-Khansari ، beroz nikbin, hassan hafezzadeh ، alireza garjani. Anti-angiogenic effects of metformin, an AMPK activator, in human umbilical vein endothelial cell and granulation tissue in rat. Oral presentation in: 20th Iranian Congress of Physiology and Pharmacology; October 2011, Hammadan, Iran.

 Arash Khorrami ، Mojtaba Ziaee ، Sina Andalib ، Mehdi Rasouly ، Alireza Garjani. The inhibitory effect of pentoxifylline on inflammation and angiogenesis in air pouch model. 20th Iranian Congress of Physiology and Pharmacology; October 2011, Hammadan, Iran.

 Alireza Garjani, Hamid Soraya, Safar Farajnia. The Role of Adenosine Monophosphate-Activated Protein Kinase (AMPK) In Cardioprotection. Oral presentation in: 20th Iranian Congress of Physiology and Pharmacology; October 2011, Hammadan, Iran.

 A. Banani, S. Mostafalou , A. Garjani , N. Maleki-Dizaji. NAAG REDUCES NEUTROPHIL INFILTRATION AND EDEMA RESPONSE IN CARRAGEENAN-INDUCED ACUTE INFLAMMATION. Presented in: 10th World Congress on Inflammation. Published in: INFLAMMATION; 2011-1471.

 N. Esfahanian, Y. Shakiba , M. GAZI KHANSARI, B. NIKBIN , N. MALEKI-DIZAJI, A. GARJANI. EFFECTS OF METFORMIN ON ANGIOGENESIS ASSESSED AS PROLIFERATION AND MIGRATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. Presented in: 10th World Congress on Inflammation. Published in: INFLAMMATION; 2011-11547.

  Alireza Garjani; Moslem Najafi (2005) Carnitine and ischaemic/reperfusion arrhythmias: antiarrhythmic or arrhythmogenic? 17th Iranian Congress of Physiology & Pharmacology, Kerman-Iran, 1-4 October, O104

2. Moslem Najafi, Alireza Garjani (2005) Cardioprotective effects of L-carnitine on myocardial ischemia and reperfusion injury in isolated rat hearts. Journal of Molecular  and Cellular Cardiology, 38, issue 6, 1049 Nasrin Maleki, Alireza Garjani, Rezvanieh salehi, Javad Lotfipour (2005)The Effects of Diltiazem on QT-interval duration and dispersion in patients with unstable Angina. Journal of Molecular  and Cellular Cardiology, 38, issue 6, 1043

3. Alireza Garjani; Moslem Najafi (2005) The Effects of L-carnitine on Ischemic and reperfusion arrhythmias in isolated rat hearts. Journal of Molecular  and Cellular Cardiology, 38, issue 6, 1024

4. Garjani, M. Shamsmohammadi, S. Kabiri, M. Salimnejad, V. Baghchevan (2004) The survey of advers drug events in hospitalized patients in Emam Hospital in 2001 in Tabriz. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

5. Garjani, T. Eterafoskouei. M. Najafi, M Shoja. (2004) Bioequivalence study of two preparations of carbamazepin tablet (200 mg) in healthy volunteers. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

6. Garjani, M. Salimnejad, M. Shamsmohammadi. (2004) Study of the effect of an interactive group discussion among physicians to promote rational use of drugs. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26. ;

7. M. Najafi, A. Garjani (2004) A modified method for precise determination of infarct size in the ischemic hearts. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

8. M. Najafi, A. Garjani (2004) Preliminary study of L-carnitine effects on infarct size in the ischemic hearts. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

9. F. Fathiazad, A. Garjani, S Ranjdoost, A. Motavallian. (2004) Hypoglycemic effects of Urtica dioica (nettle) on diabetic and normal rats. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

10.M. Barzegar-Jalali, A. Barzegar-Jalali, S. Dastmalchi, A. Garjani, N. Maleki, S. Beheshti. (2004) Correlation of dissolution rate of glibenclamide with its serum level and hypoglycemic effect. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

11.N. Maleki, A. Garjani, H. Nazemiyeh (2004) Anti-inflammatory and anti-leukocyte accumulation effects of Stachys schtschegleevii. 9th Seminar of Pharmaceutical Sciences, Tabriz, Iran, Aug 23-26.

12.Garjani, N. Maleki, T. Eterafoskouei, M. Solemanipoya, H. Nazemieh (2003) Topical anti-inflammatory activity of extract from aerial parts of Stachys inflata on rat. Inflammation Research, Supplement 2, Vol 52, P: S106

13.N. Maleki, ARM Nayebi, A. Garjani, M Salymnejad, R. Rahimi (2003) reduction of inflammation following intracerebroventricular parachloro phenyl alanine and serotonin: Time is determinative. Inflammation Research, Supplement 2, Vol 52, P: S116

14.N. Maleki, F. Fathiazad, A. Garjani, M. Safaii (2003) Study on the anti-inflammatory and anti-nociceptive effects of Danae racemosa. Inflammation Research, Supplement 2, Vol 52, P: S119

15.N. Maleki, Z Farshnahali, H Nazemiyeh, A. Garjani (2003) The anti-inflammatory effect of 11 fractions of ethyl acetate extracts of aerial part of Stachys inflata. Inflammation Research, Supplement 2, Vol 52, P: S121

16.Garjani, S Davaran, M. Rashidi, N. Maleki, Sh. Javadi (2003) Protective effects of some azo polymeric and non-polymeric prodrugs of 5-aminosalicylic acid on acid-induced rat colitis. Inflammation Research, Supplement 2, Vol 52, P: S124

17. Ansari Maleki D., Garjani A., Najafi M., Hemmati S. (2002),EFFECTS OF DIMETHYL SULFOXIDE (DMSO) AND DIMETHYL FORMAMIDE (DMF) ON ISOLATED RAT HEART. 8th Iranian Seminar of Pharmaceutical Sciences, Shiraz, Iran, 27-29 Aug.

18.Garjani A., Najafi M., Ansari Maleki D., Hemmati S. (2002),EFFECTS OF TWO NEW MILRINONE ANALOGUES ON ISOLATED RAT HEART. 15th Iraniasn Congress of Physiology and Pharmacology, Shiraz, Iran,

19.Garjania A., Maleki N. (2002),ISHAEMIC PRECONDITIONING AS A NEW CONCEPT FOR PREVENTION OF INFLAMMATION. 8th Iranian Seminar of Pharmaceutical Sciences, Shiraz, Iran, 27-29 Aug.

20.Fathiazad F., Maleki N., Safaii M., Garjani A. (2002),STUDY ON THE ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF DANAE RACEMOSA. 8th Iranian Seminar of Pharmaceutical Sciences, Shiraz, Iran, 27-29 Aug.

21.Papazh H., Fathiazad F., Maleki N., Garjani A. (2002) ,STUDY ON THE ANTI-INFLAMMATORY EFFECTS OF ACHILLEA MILLEFOLIUM IN CARRAGEENAN-INDUCED PAW OEDEMA IN THE RATS. 8th Iranian Seminar of Pharmaceutical Sciences, Shiraz, Iran, 27-29 Aug.

22.Maleki N., Mohajjel Nayebi A., Salimnejad M., Rahimi R., Garjani A. (2002),THE EFFECTS OF SEROTONIN-DEPLETION BY pCPA  ON CARRAGEENAN INDUCED PAW OEDEMA. 8th Iranian Seminar of Pharmaceutical Sciences, Shiraz, Iran, 27-29 Aug.

23.Alireza Garjani, Nasrin Maleki, Hossein Nazemiyeh & Abdolahad Mansori (2001).THE EFFECTS OF STACHYS INFLATA ON MYOCARDIAL INFARCT SIZE IN RATS. XVII World Congress of the International Society for Heart Research, Winnipeg, Manitoba, Canada, July 6-11

24.Nasrin Maleki, Alireza Garjani, Ashraf Fakhrjoo, Nahide Nilfouroushan & Zahra Farshnahali (2001).  ISCHAEMIC PRECONDITIONING: FROM CARDIOPROTECTION TO PROTECTION AGAINST INFLAMMATION. XVII World Congress of the International Society for Heart Research, Winnipeg, Manitoba, Canada, July 6-11

25.Garjani, F. Fathie, N. Maleki and M. Moghadam (2001).HYPOGLYCEMIC EFFECTS OF SOME IRANIAN HERBS USED FOR THE TREATMENT OF DIABETES MELITUS. 9th asian-Pacific Congress of Clinical Biochemistry; Hotel Ashok, New Delhi, India, 11-16 November

26.Rashidi M.R., Garjani A., Davaran S., Nilfrooshan N. & Shirzadegan H. (2000).Effects of Some New Azo Polymeric Pro-Drug of 5-Amino Salicylic Acid on the Treatment of Colitis in Rats. 7th Iranian Seminar of Pharmaceutical Sciences (ISPS), 26-28 August, Mashhad, Iran.

27.Maleki N., Garjani A., Nazemiyeh H. & Nilfrooshan (2000). The Effects of Hydroalcoholic Extract From Aerial Parts of Stachys Inflata On Myeloperoxidase Activity. N. 7th Iranian Seminar of Pharmaceutical Sciences (ISPS), 26-28 August,  Mashhad, Iran.

28.Maleki N., Jafari-Azad P., Garjani A. and Barzegar-Jalali M. (2000).Effects of Improvement of Dissolution Rate by Solvent Deposition Technique on Blood Levels of Glybenclamide in Normal Rabbits. 7th Iranian Seminar of Pharmaceutical Sciences (ISPS), 26-28 August, Mashhad, Iran.

29.Najafi M., Khosrowshahi M.B. & Garjani A. (2000). Bioequivalance Study on Two Preparations of Phenobarbital Tablet (100mg) in Healthy Volunteers. 7th Iranian Seminar of Pharmaceutical Sciences (ISPS), 26-28 August, Mashhad, Iran.

30.Rezazadeh H., Gandiha A., Garjani A., Nayebi A., Babaei H. & Athar M. (1999).Iron Overload Augments Croton Oil-Mediated Tumour Promoution in Mouse Skin. 14th Iranian Congress of Physiology and Pharmacology, 16-20 May, Tehran, Iran

31.Garjani, A. Mahdinia and N Maleki (1998).Preconditioning Following Hypoventilation of The Anaesthetized Rats Before Coronary Artery Occlusion. Archives of Pharmacology, Supplement 2 to Volume 358 No 1 (1998), R618, XIIIth International Congress of Pharmacology, 26-31 July, Munchen, Germany

32.Nasrin Maleki Dizaji, H. Nasemie and A. Garjani, (1998).Study on the Anti-Inflammatory Effects of Stachys  Inflata in Carragenan and Formalin-Induced Paw Oedema in the Rat., Archives of Pharmacology, Supplement 2 to Volume 358 No 1 (1998) R493, XIIIth International Congress of Pharmacology, 26-31 July, Munchen, Germany

33.M.S. Hejazi, Parvizi R., Jelvegari M., Garjani A. & Azizian P. (1998).Formulation of Cardioplegia Ampule and comparison with Foreigner sample. 6th Iranian Congress of Pharmaceutical Sciences (ISPS), 26-27 August, Isfahan, Iran.

34.Garjani, H. Nazemieh, N. Maleki & J. Afshar.(1997) Antiarrhythmic Effects of Crataegus meyeri on ischaemic arrhythmias in rats. International Society for Heart Research, Versailles, france, February 1-5

35.H. Valizadeh, H. Nazemieh, N. Maleki & A. Garjani. (1997). Antiarrhythmic Effects of Iranian Species of Cratagus on Ischaemic Arrhythmias in Rat Heart. The First Congress of Medicinal Plants and Idustry, Shiraz, Iran, May 13-15.

36.V. Baghchevan Ghadimi, A. Garjani, M. Barzegar-Jalali, N. Maleki, M.R. Siahi, (1997). Improvement of Dissolution Rate and BSL Lowering of Glibenclamide in Normal Rabbits, The Fifth Iranian Conference of Pharmaceutical Sciences. 9-10 August, Tehran, Iran

37.Garjani A., Maleki N. (1997). Increased plasma level of endothelin accompanying myocardial ischaemia in rats dose not originate in the myocardium. 13th Iranian Congress of Physiology and Pharmacology, Isfahan, Iran, 26-29 August, 193-194.

38.Maleki N., Jabbari R. & Garjani A. (1997).Study on the Anti-Inflammatory Effects of Solvent Deposition Formulation and powder of piroxicam in Carragenan Induced Paw Oedema in the Rat. 13th Iranian Congress of Physiology and Pharmacology, Isfahan, Iran, 26-29 August, 279-280.

39.Isaac J. Zeitlin, Maqsood Ahmad, Denise G. Campbell and Alireza Garjani. (1995),Modulation of kinin outflow from isolated perused rat hearts by endothelin-1. 14th International Symposium on Kinins; Denver, USA, 10-15 September 1995

40.I.J. Zeitlin and A. Garjani. (1995),Metabolism of ET-1 and bigET-1 in rat myocardium. J. Mol. Cell. Cardiol. 27, A98

41.Garjani A., Zeitlin I.J. & Wainwright C.L. (1994). Degradation of endothelin-1 in rat myocardium. J. Physiol. (london), 475, 85

42.Garjani A., Wainwright C.L., Zeitlin I.J., Wilson C. & Slee S.J. (1994).The effects of ETA-receptor antagonist, BQ123, on ischaemic arrhythmias and myocardial infarct size in anaesthetized rats. Br. J. Pharmacol., 112. 159

43.Garjani A., Wainwright C.L. & Zeitlin I.J. (1994).Preliminary characterization of enzymes involved in endothelin-1 degradation by rat myocardium. Canadian J. Physiol. Pharmacol., 72(Suppl. 1), 175.

44.Garjani A., Wainwright C.L., Zeitlin I.J. (1994).The endothelin receptor antagonist, BQ123, reverses the pro-arrhythmic effect of ET-1 in anaesthetized rats. Br. J. Pharmacol., 113, 46

45.Garjani A., Wainwright C.L. & Zetlin I.J. (1993).Endothelin-1 increases the severity of ischaemia-induced arrhythmias in anaesthetized rats. Br. J. Pharmacol., 109, 129

46.Hadyloo M., Garjani A. and Gandiha A. (1989).Studies on the Blocking Action of Tetracyclin at Neuromascular Junction of the Chicken. 9th Iranian Congress of Physiology and Pharmacology, Tehran, Iran, 26-29 May.

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