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22 September 2017
 
Maryam Hamzeh-Mivehroud, Ph.D

Title:Assistant Professor of Medicinal Chemistry
Department:Medicinal Chemistry
Office Phone:+98(41) 33372250-51
Fax: +98(41) 33344798
E-mail:hamzehm@tbzmed.ac.ir , maryam_h_7860@yahoo.com


EDUCATION
:
  • 2005-2011:Doctor of Philosophy (PhD) (Medicinal Chemistry), Tabriz University of Medical Sciences, Iran
  • 1999-2004:Doctor of Pharmacy (Pharm.D), Tabriz University of Medical Sciences, Iran
  • 2010:Occupational trainee course of PhD under supervision of Prof. Joel Mackay in School of Molecular Biosciences, Sydney University, Sydney, Australia
POSITION HELD:
  • April 2011 - May 2012: Academic member at the Biotechnology Research Center, Tabriz University of Medical Sciences, Iran
  • May 2012 – present: Academic member at School of Pharmacy, Tabriz University of Medical Sciences, Iran
AWARDS:
  • Best undergraduate student research award at the School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran, 2003.
  • Best student poster prize in  9th Iranian Seminar of Pharmaceutical Sciences, 23-26 August, Tabriz, Iran, 2004.
  • Top second university undergraduate student award, Tabriz University of Medical Sciences, Tabriz, Iran, 2005.
  • Best poster prize in 20th EuroQSAR conference, 31 August-04 September, St. Petersburg, Russia, 2014.
RESEARCH AREAS:
  • Molecular modelling
  • QSAR studies
  • Phage display
  Publications

Quantitative structure activity relationship and docking 
studies of imidazole-based derivatives as P-glycoprotein inhibitors
Quantitative structure activity relationship and docking 
studies of imidazole-based derivatives as P-glycoprotein inhibitors
Quantitative structure activity relationship and docking 
studies of imidazole-based derivatives as P-glycoprotein inhibitors

1) Abolhasani H, Zarghi, A, Hamzeh-Mivehroud M, Alizadeh AA, Shahbazi Mojarrad J and Dastmalchi S (2014) In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies. Iranian Journal of Pharmaceutical Research; In press. 

2) Hamzeh-Mivehroud M, Rahmani S, Hosseinpour Feizi MA and Dastmalchi S  and Rashidi MR
 (2014) In vitro and in silico studies to explore structural features of flavonoids aldehyde oxidase inhibition. Archiv der Pharmazie; 347(10): 738-47.

3) Ghandadi M, Shayanfar A, Hamzeh-Mivehroud M and Jouyban A (2014) Quantitative structure activity relationship and docking studies of imidazole-based derivatives as P-glycoprotein inhibitors. Medicinal Chemistry Research; 23:4700-12.

4) 
Abolhasani H, Zarghi A, Abolhasani A, Hamzeh-Mivehroud M, Bargahi N, Notash B, Shahbazi Mojarrad J and Dastmalchi S (2014) Design, Synthesis and in vitro Cytotoxicity Evaluation of new 3', 4'-bis (3, 4, 5-Trisubstituted)-4'H-Spiro [Indene-2, 5'-Isoxazol]-1(3H)-one Derivatives as Promising Anticancer Agents. Letters in Drug Design & Discovery; 11:1149-61.

5) Hamzeh-Mivehroud M, Alizadeh AA, Morris MB, Church WB and Dastmalchi S (2013) Phage Display as a Technology Delivering on the Promise of Peptide Drug Discovery. Drug Discovery Today; 18(23-24):1144-57.

6) Hamzeh-Mivehroud M, Rahmani S, Rashidi MR, Hosseinpour Feizi MA and Dastmalchi S (2013) Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids. Xenobiotica; 43(8):661-70.

7) Hamzeh-Mivehroud M, Mahmoudpour A and Dastmalchi S (2012) Identification of new peptide ligands for epidermal growth factor receptor using phage display and computationally modeling their mode of binding. Chemical Biology and Drug Design 79:246-259.

8) Hamzeh-Mivehroud M, Alizade AA, Ahmadifar M and Dastmalchi S  (2012) In silico Evaluation of Crosslinking Effects on Denaturant meq values and DCp upon Protein Unfolding. Avicenna Journal of Medical Biotechnology; 4(1): 23-34.

9) Dastmalchi S, Hamzeh-Mivehroud M and Asadpour-Zeynali, K (2012) Comparison of different 2D and 3D-QSAR methods on activity prediction of histamine H3 receptor antagonists. Iranian Journal of Pharmaceutical Research 11 (1): 97-108.

10) Hamzeh-Mivehroud M, Dastmalchi S and Ahmadzadehnia, N. (2011) 2D and 3D Quantitative Structure Activity Relationship studies of Human Microsomal Epoxide Hydrolase Inhibitors Clinical Biochemistry 44:S104.

11) Hamzeh-Mivehroud M, Mahmoudpour A, Rezazadeh H and Dastmalchi S (2008) Non-specific translocation of peptide-displaying bacteriophage particles across the gastrointestinal barrier. European Journal of Pharmaceutics and Biopharmaceutics 70: 577-581.

12) Dastmalchi S, Hamzeh-Mivehroud M, Ghafourian T and Hamzeiy H (2008) Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists. Journal of Molecular Graphics and Modelling 26: 834-844.

13) Jouyban A, Fakhree M.A.A, Hamzeh-Mivehroud M and  Acree Jr  W.E (2007) Modelling the deviations of solubilities in water-dioxane mixtures from predicted solubilities by the Jouyban-Acree model. Journal of Drug Delivery Science and Technology 17:359-363.

14) Dastmalchi S and Hamzeh-Mivehrod M (2005) Molecular modelling of human aldehyde oxidase and identification of the key interactions in the enzyme-substrate complex. DARU 13: 82-93.


 Presentations:

ABSTRACTS:

1) Dastmalchi S and Hamzeh-Mivehroud M. (2004) Molecular modelling of human aldehyde oxidase and development of a 3D-QSAR model for analysis of enzyme-substrate interactions. 9th Iranian Seminar of Pharmaceutical Sciences, 23-26 August, Tabriz, Iran.

2) Barzegar-Jalali M, Dastmalchi S and Hamzeh-Mivehroud M. (2004) Novel model independent parameters for comparison of drug dissolution from different formulations. 9th Iranian Seminar of Pharmaceutical Sciences, 23-26 August, Tabriz, Iran.

3) Dastmalchi S, Hamzeh-Mivehrod M. (2004) Molecular modelling of human aldehyde oxidase. Proceeding of the ninth Australian Molecular Modelling Conference, 30 June-3 July, Sydney, Australia.

4) Dastmalchi S, Ghafourian T and Hamzeh-Mivehroud M. (2006) A combined PLS-MLR quantitative structure-activity relationship study on histamine H3 receptor antagonists. 10th Iranian Pharmaceutical Sciences Conference, 21-24 August, Tehran, Iran.

5) Rajabi A, Hamzeh-Mivehroud M., Ghafourian T and Barzegar-Jalali, M (2006) Prediction of intestinal absorption using the principles of absorption potential and support vector machines. 10th Iranian Pharmaceutical Sciences Conference, 21-24 August, Tehran, Iran.

6) Jouyban A, Hamzeh-Mivehroud M. (2006) Solubility estimation of drugs in water-dioxane mixtures using Jouyban-Acree model. 10th Iranian Pharmaceutical Sciences Conference, 21-24 August, Tehran, Iran.

7) Dastmalchi S, Hamzeh-Mivehroud M and Ghafourian T. (2006) Molecular Modeling of Human H3 receptor. 7th Iranian Biophysical Chemistry Conference 18-19 July, Tabriz, Iran.

8) Jouyban A, Hamzeh-Mivehroud M and Nora Y. K. CH. Solubility prediction of salicylic acid in water-dioxane mixture. (2007) 15th Iranian Society Analytical Chemistry Congress  27 Feb-1 Mar, Shiraz, Iran

9) Dastmalchi S, Mahmoudpour A, Rezazadeh H and Hamzeh-Mivehroud M. Selection of polypeptide vehicles for delivering therapeutical agents across the GI epithelial using phage display technology. (2007) 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology 29 Oct- 1 Nov, Shiraz, Iran.

 10) Hamzeh-Mivehroud M, Dastmalchi S and Asadpour-Zeynali K. Comparison of different 2D and 3D-QSAR methods on activity prediction of histamine H3 receptor antagonists. (2008) 11th Iranian Pharmaceutical Sciences Conference 18-21 Aug, Kerman, Iran.

 11) Ahmadifar M, Dastmalchi S and Hamzeh-Mivehroud M, Investigation of thermodynamic stability of proteins based on sequence and structural constraint. (2008) 11th Iranian Pharmaceutical Sciences Conference 18-21 Aug, Kerman, Iran.

 12) Hamzeh-Mivehroud M, Dastmalchi S and Ahmadzadehnia N. 2D and 3D Quantitative Structure Activity Relationship studies of Human Microsomal Epoxide Hydrolase Inhibitors. (2011) 12th Iranian Congress of Biochemistry & 4th International Congress of Biochemistry & Molecular Biology 6-9 Sep, Mashhad, Iran.

13) Hamzeh-Mivehroud M, Dastmalchi S, Molecular modeling studies in identification of interactions between GE11 peptide ligand and EGFR (2011) 7th National Biotechnology Congress. 12-14 Sep, Tehran, Iran.

 14) Hamzeh-Mivehroud M, Dastmalchi S, Using artificial neural network (ANN) method to predict the activity of epoxide hydrolase inhibitors (2011) 3rd Iranian biannual Seminar of Chemometrics 9-10 Nov, Tabriz, Iran.

 15) Tahghighi A, Hamzeh-Mivehroud M, Asadpour Zeynali, K, Foroumadi A, Dastmalchi S. Quantitative structure-activity relationship analyses of antileishmania activity of 5-(5-nitroheteroaryl-2-y1)-1,3,4-thiadiazole derivatives (2011) 3rd Iranian biannual Seminar of Chemometrics 9-10 Nov, Tabriz, Iran.

 16) Rahmani S, Dehghan G, Feizi M, Hamzeh-Mivehroud M, Rashidi M. QSAR modeling of some flavonoids as inhibitors of phenanthridine oxidation by aldehyde oxidase (2011) 3rd Iranian biannual Seminar of Chemometrics 9-10 Nov, Tabriz, Iran.

 17) Hamzeh-Mivehroud M and Dastmalchi, S.  In Silico modeling of receptor binding mode for two novel peptides developed as EGFR antagonists (2012) The First International & 11th Iran Biophysical Chemistry Conference 13-15 June, Ardebil, Iran.

 18) Alizadeh AA, Hamzeh-Mivehroud M and Dastmalchi, S.  Effects of structural constraints on thermodynamic parameters of protein unfolding. (2012) The First International & 11th Iran Biophysical Chemistry Conference 13-15 June, Ardebil, Iran.

 19) Rahbar M, Hamzeh-Mivehroud M and Dastmalchi, S. Bioinformatic Analysis and molecular modeling of DOF domain proteins (2012) The First International & 11th Iran Biophysical Chemistry Conference 13-15 June, Ardebil, Iran.

20) Hamzeh-Mivehroud M, Dastmalchi, S. Identification of new peptide ligands for epidermal growth factor receptor using phage display technology (2012) 13th Iranian Pharmaceutical Sciences Congress 3-6 September, Isfahan, Iran.

21) Ghandadi M, Shayanfar A, Hamzeh-Mivehroud M, Jouyban A. Quantitative structure activity relationship and docking studies on imidazole derivatives as P-glycoprotein inhibitors (2012) 13th Iranian Pharmaceutical Sciences Congress 3-6 September, Isfahan, Iran.

22) Rahbar M, Hamzeh-Mivehroud M and Dastmalchi, S. Cloning, expression, and purification of DOF5.8 zinc finger domain (2012) 13th Iranian Pharmaceutical Sciences Congress 3-6 September, Isfahan, Iran.

23) Alizadeh A, Hamzeh-Mivehroud M, Farajzadeh M, Dastmalchi S. Cloning, expression, and purification of human TNF-α (2012) 13th Iranian Pharmaceutical Sciences Congress 3-6 September, Isfahan, Iran.

24) Safarizad A, Hamzeh-Mivehroud M, Karimi S, Farajzadeh M, Farajzadeh D and Dastmalchi S. Design and Molecular modeling of a humanaized  scFv  antibody against hTNF-α and investigation of their interactions (2013) 1st Tabriz International Life Science Conference and 12th  Iran Biophysical Chemistry Conference 22-24 May, Tabriz, Iran.

25) Hamzeh-Mivehroud M, Alizadeh A, Sokouti B and Dastmalchi S. An alignment independent 3D QSAR study on a series of TNF-alpha converting enzyme inhibitors (2014) 20th EuroQSAR 31 August-04 September, St. Petersburg, Russia.  


  TEACHING EXPERINCES
Medicinal Chemistry
Department of Medicinal Chemistry
School of Pharmacy
Tabriz University of Medical Sciences
Tabriz, Iran


General Chemistry
Paramedical Faculty
Tabriz University of Medical Sciences
Tabriz, Iran

Practical Analytical Chemistry

Department of Medicinal Chemistry
School of Pharmacy
Tabriz University of Medical Sciences
Tabriz, Iran

Practical General Chemistry
Department of Medicinal Chemistry
School of Pharmacy
Tabriz University of Medical Sciences
Tabriz, Iran

Practical Statistics
Department of Medicinal Chemistry
School of Pharmacy
Tabriz University of Medical Sciences
Tabriz, Iran

Protein purification
Biotechnology Research Center
Tabriz University of Medical Sciences
Tabriz, Iran


Posted by   Farnam Norouzi