This department offers higher education in the field of Pharmaceutics to students holding a Pharm.D degree, and has accepted students to study for a doctorate degree (Ph.D) in Pharmaceutics since 1994. Subject areas taught by this department include: homogeneous and heterogeneous dosage forms, physical pharmacy, biopharmacy and pharmacokinetics, industrial pharmacy, physicochemical and microbial control of dosage forms.
The first intake of Ph.D students received their degrees in 1997 and at present six students are in the process of completing the said course. The curriculum includes the following subjects: physical pharmacy, biopharmacy and pharmacokinetics, medicinal technology, chemical and physical control of medicines, and cosmetic sciences. Students should pass at least 20 units within 5-6 years. After studying the aforementioned subject matters for 2 years, the applicants meet the admission requirements for research in the field of medicinal sciences. In order to be awarded the Ph.D certificate, success in the research-based thesis is required.
AREAS OF RESEARCH
- Preparation of novel controlled - release formulations ─ This includes osmotic pumps, microencapsulation of drugs, liposomes, etc. An attempt is being made to obtain zero order release formulations using different kinds of polymers and excipients. The affecting parameters on release rate from different formulations are being investigated.
- Solubility and solubilisation of medicines ─ Research in this field is carried out theoretically (model-making) and practically. Research involves applying principles of co-solvency to the formulation of dosage forms such as solutions of lorazpom, furosemide and hydrocortisone.
- Stability of Pharmaceutical substances ─ An attempt is being made to study the effects of various excipients with different physicochemical properties on the chemical stability of drugs, with an aim to select the best excipient which can be used in the formulation of unstable drugs.
- Bioavailibility of drugs ─ This includes the methods of increasing the dissolution rate of poorly soluble drugs by techniques of solid dispersion or solvent deposition. These methods are used for the preparation of anti-diabetic and anti-inflammatory medicines and the absorption of these medicines are investigated both theoretically and practically. The effect of formulation variables on bioavailability of anti- diabetic medicines is also being investigated.
- Deformation of crystals for improvement of mechanical properties of drugs which have not good compressibility and compactibility─ The aim of this study is to investigate the effects of impurity or additives, type of solvent and the cooling rate on the shape and deformation of crystals (plasticity and elasticity of drug and excipients). In this research, we try to increase compression and compaction properties of poorly compactible drugs and excipients.